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At baseline, age and the proportion of subjects with heart failure, prior ischemic heart disease, prior MI, prior stroke and who used insulin were higher in the CVOTs than in the pooled glycemic efficacy trials, while low-density lipoprotein (LDL)-cholesterol, estimated glomerular filtration rate (eGFR) and the proportion of current smokers were higher in the glycemic efficacy trials than in the CVOTs
Interplay of gut microbiota, glucagon-like peptide receptor agonists, and nutrition: new frontiers in metabolic dysfunction-associated steatotic liver disease therapy
From a clinical perspective, these metabolic considerations suggest that structured nutritional monitoring may accompany long-term GLP-1RA therapy, particularly in individuals with increased susceptibility to lean mass loss or micronutrient insufficiency
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